Office of
the Director, HIV Drug Resistance Program Stephen
H. Hughes, Ph.D., Director Stephen
Oroszlan, Ph.D., Scientist Emeritus
Retroviral
Replication Laboratory Stephen
H. Hughes, Ph.D., Chief, Retroviral Replication Laboratory; Head, Vector
Design and Replication Section
- Retroviral replication
- Structure and function of
HIV reverse transcriptase
- Retroviral vectors
David
Derse, Ph.D., Head, Retrovirus Gene Expression Section
- Comparative retrovirology
- Mechanisms of HIV-1 and
HTLV-1 infection and replication
- Control of cell and virus gene expression
-
Viral pathogenesis and persistence
Eric
O. Freed, Ph.D., Head, Virus-Cell Interaction Section
- HIV and retroviral assembly and release
- Interactions
between viral and cellular proteins
- Trafficking of retroviral proteins
-
Envelope glycoprotein incorporation and function
Wei-Shau
Hu, Ph.D., Head, Viral Recombination Section
- Mechanisms of reverse transcription and recombination
-
RNA packaging and virus assembly
- HIV replication
- Interactions
between distinct viruses
Vineet
N. KewalRamani, Ph.D., Head, Model Development Section
- Virus-host interactions
- Cofactors in HIV infection
-
Development of animal models for HIV infection
Stuart
F.J. Le Grice, Ph.D., Head, RT Biochemistry Section
- Protein and nucleic acid footprinting
- Bioconjugate evaluation of
reverse transcription complexes
- RNase H inhibitors
- Unnatural
amino acids as probes of protein function
Vinay
K. Pathak, Ph.D., Head, Viral Mutation Section
- Structure and function of APOBEC3 host restriction factors
-
Mechanisms of antiviral drug resistance
- Reverse transcriptase structure,
fidelity, and template switching
Alan
Rein, Ph.D., Head, Retrovirus Assembly Section
- Molecular mechanisms of retroviral assembly and replication
-
Interactions of retroviral proteins with nucleic acids
- Interactions of
retroviral components with host antiviral factors
Host-Virus Interaction Branch
Frank
Maldarelli, M.D., Ph.D., Head, In Vivo Biology Group
- HIV-1 population genetics in vivo
- Source of
low-level viremia in patients suppressed on antiretroviral therapy
- Clinical
studies on HIV resistance
Mary
Kearney, Ph.D., Manager, Virology Core Facility
CONSULTANTS:
John
M. Coffin, Ph.D., American Cancer Society Research Professor, Tufts University
John
W. Mellors, M.D., Chief, Division of Infectious Diseases, University of
Pittsburgh
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