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| ... |              | ... | Full PubMed List of Publications by V.K. Pathak
Moore, M.D., Fu, W., Soheilian, F., Nagashima, K., Ptak, R.G., Pathak, V.K., and Hu, W.-S. (2008) Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: Effects on virion morphogenesis and RNA maturation. Virology, in press. Delviks-Frankenberry, K.A., Nikolenko, G.N., Boyer, P.L., Hughes, S.H., Coffin, J.M., Jere, A., and Pathak, V.K. (2008) HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. Proc. Natl. Acad. Sci. USA, in press. Mbisa, J., K.A. Delviks-Frankenberry, J.A. Thomas, R.J. Gorelick, and Pathak, V.K. (2008) Real-time PCR analysis of HIV-1 replication post-entry events. In Prasad, V., and Kalpana, G. (eds.), HIV Protocols, 2nd Ed., Humana Press, Inc., in press. Chen,
J., Pathak, V.K.,
Peng, W., and Hu, W.-S.
(2008) Capsid proteins from human immunodeficiency virus type 1 and simian
immunodeficiency virus SIVmac can coassemble into mature cores of infectious
viruses. J. Virol.,
in press (June 25 Epub ahead of print). Nikolaitchik, O.A., Gorelick, R.J., Leavitt, M.G., Pathak, V.K., and Hu, W.-H.
(2008) Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication. Virology 375: 539-549. Santos, A.F., Lengruber, R.B., Soares, E.A., Jere, A., Sprinz, E., Martinez, A.M., Silveira, J., Sion, F.S., Pathak, V.K., and Soares, M.A. (2008) Conservation patterns of HIV-1 RT connection and RNase H domains: Identification of new mutations in NRTI-treated patients. PLoS ONE 3: e1781. [Abstract] [Full-text PDF article] Brehm, J.H., Koontz, D., Meteer, J.D., Pathak, V., Sluis-Cremer, N., and Mellors, J.W. (2007) Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine. J. Virol. 81: 7852-7859. [Abstract] [Full-text PDF article] Russell, R.A., and Pathak, V.K. (2007) Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F. J. Virol. 81: 8201-8210. [Abstract] [Full-text PDF article] Mbisa,
J.L., Barr, R., Thomas, J.A., Vandergraaff, N., Dorweiler, I.J., Svarovskaia,
E.S., Brown, W.L., Mansky, L.M., Gorelick, R.J., Harris, R.S., Engelman, A., and
Pathak, V.K. (2007) Human immunodeficiency virus type 1 cDNAs
produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer
and integration. J. Virol. 81: 7099-7110. Delviks-Frankenberry, K.A., Nikolenko, G.N., Barr, R., and Pathak, V.K. (2007) Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance. J. Virol. 81: 6837-6845. [Abstract] [Full-text PDF article] Thomas,
D.C., Voronin, Y.A., Nikolenko, G.N., Chen, J., Hu, W.-S., and Pathak, V.K.
(2007) Determination of the ex vivo rates of human immunodeficiency virus
type 1 reverse transcription by using novel strand-specific amplification analysis.
J. Virol. 81: 4798-4807. Xu,
H., Chertova, E., Chen, J., Ott, D.E., Roser, J.D., Hu, W.-S., and Pathak,
V.K. (2007) Stoichiometry of the antiviral protein APOBEC3G in
HIV-1 virions. Virology 360: 247-256. Nikolenko, G.N., Delviks-Frankenberry, K.A., Palmer, S., Maldarelli, F., Fivash, M.J., Jr., Coffin, J.M., and Pathak, V.K. (2007) Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance. Proc. Natl. Acad. Sci. USA 104: 317-322. [Abstract] [Full-text PDF article]
Voronin, Y.A., Sidorov, I.A., and Pathak, V.K. (2006) A probability
model predicting initiation efficiency of retroviral vectors with two primer-binding
sites. J. Theoret. Biol. 242: 347-355. Boyko,
V., Leavitt, M., Gorelick, R., Fu, W., Nikolaitchik, O., Pathak, V., Nagashima,
K., and Hu, W.-S. (2006) Coassembly and complementation of Gag proteins
from HIV-1 and HIV-2, two distinct human pathogens. Mol. Cell 23: 281-287.
Krajewski,
K., Zhang, Y., Parrish, D., Deschamps, J., Roller, P.P., and Pathak, V.
(2006) New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene
scaffold: Synthesis, resolution, and inhibitory activity. Bioorg. Med. Chem.
Lett. 16: 3034-3038. Fu,
W., Dang, Q., Nagashima, K., Freed, E.O., Pathak, V.K., and Hu, W.-S.
(2006) Effects of Gag mutation and processing on retroviral dimeric RNA
maturation. J. Virol. 80: 1242-1249. Chen, J., Dang, Q., Unutmaz, D., Pathak, V.K., Maldarelli, F., Powell, D., and Hu, W.-S. (2005) Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: Preference in virus entry is important but is not the sole factor. J. Virol. 79: 4140-4149. [Abstract] [Full-text PDF article] Nikolenko, G.N., Palmer, S., Maldarelli, F., Mellors, J.W., Coffin, J.M., and Pathak, V.K. (2005) Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision. Proc. Natl. Acad. Sci. USA 102: 2093-2098. [Abstract] [Full-text PDF article] Mbisa,
J.L., Nikolenko, G.N., and Pathak, V.K. (2005) Mutations in
RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease
efficiency and accuracy of plus-strand DNA transfer. J. Virol. 79: 419-427.
Williams,
K.L., Zhang, Y., Shkriabai, N., Karki, R.G., Nicklaus, M.C., Kotrikadze, N., Hess,
S., Le Grice, S.F.J., Craigie, R., Pathak, V.K., and Kvaratskhelia, M.
(2005) Mass spectrometric analysis of the HIV-1 integrase:pyridoxal-5'-phosphate
complex reveals a new binding site for a nucleotide inhibitor. J. Biol.
Chem. 280: 7949-7955. Nikolenko,
G.N., Svarovskaia, E.S., Delviks, K.A., and Pathak, V.K. (2004)
Antiretroviral drug resistance mutations in human immunodeficiency virus type
1 reverse transcriptase increase template switching frequency. J. Virol.
78:8761-8770. Svarovskaia,
E.S., Xu, H., Mbisa, J.L., Barr, R., Gorelick, R.J., Ono, A., Freed, E.O., Hu,
W.-S., and Pathak, V.K. (2004) Human apolipoprotein B mRNA-editing
enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions
through interactions with viral and nonviral RNAs. J. Biol. Chem. 279: 35822-35828. Voronin, Y.A., and Pathak, V.K. (2004) Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: A quantitative in vivo assay for function of initiation complexes. J. Virol. 78: 5402-5413. [Abstract] [Full-text PDF article] Xu, H., Svarovskaia, E.S., Barr, R., Zhang, Y., Khan, M.A., Strebel, K., and Pathak, V.K. (2004) A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion. Proc. Natl. Acad. Sci. USA 101: 5652-5657. [Abstract] [Full-text PDF article] Svarovskaia,
E.S., Barr, R., Zhang, X., Pais, G., Marchand, C., Pommier, Y., Burke, T.R., Jr.,
and Pathak, V.K. (2004) Azido-containing diketo acid derivatives
inhibit human immunodeficiency virus type 1 integrase in vivo and influence the
frequency of deletions at two-long-terminal-repeat-circle junctions. J.
Virol. 78: 3210-3222. Dang,
Q., Chen, J., Unutmaz, D., Coffin, J.M., Pathak, V.K., Powell, D., KewalRamani,
V.N., Maldarelli, F., and Hu, W.-S. (2004) Nonrandom HIV-1 infection
and double infection via direct and cell-mediated pathways. Proc. Natl.
Acad. Sci. USA 101: 632-637. Voronin, Y.A., and Pathak, V.K.. (2003) Frequent dual initiation of reverse transcription in murine leukemia virus-based vectors containing two primer-binding sites. Virology 312: 281-294. [Abstract] [Full-text PDF article] Zhang,
X., Pais, G.C., Svarovskaia, E.S., Marchand, C., Johnson, A.A., Karki, R.G., Nicklaus,
M.C., Pathak, V.K., Pommier, Y., and Burke, T.R. (2003) Azido-containing
aryl beta-diketo acid HIV-1 integrase inhibitors. Bioorg. Med. Chem. Lett.
13: 1215-1219. Hu, W.-S., Rhodes, T., Dang, Q., and Pathak, V.K. (2003) Retroviral recombination: Review of genetic analyses. Front. Biosci. 8: D143-D155. [Abstract] [Full-text HTML article] Svarovskaia, E.S., Cheslock, S.R., Zhang, W.-H., Hu, W.-S., and Pathak, V.K. (2003) Retroviral mutation rates and reverse transcriptase fidelity. Front. Biosci. 8: D117-D134. [Abstract] [Full-text HTML article] Zhang,
W.-H., Svarovskaia, E.S., Barr, R., and Pathak, V.K. (2002)
Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity
of DNA synthesis in regions associated with adenine--thymine tracts. Proc.
Natl. Acad. Sci. USA 99: 10090-10095. Pais, G.C.G., Zhang, X., Marchand, C., Neamati, N., Cowansage, K., Svarovskaia, E.S., Pathak, V.K., Tang, Y., Nicklaus, M., Pommier, Y., and Burke, T.R., Jr. (2002) Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. J. Med. Chem. 45: 3184-3194. [Abstract] [Full-text PDF article] Zhang, W.-H., Hwang, C.K., Hu, W.-S., Gorelick, R.J., and Pathak, V.K. (2002) Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo. J. Virol. 76: 7473-7484. [Abstract] [Full-text PDF article] Hwang, C.K., Svarovskaia, E.S., and Pathak, V.K. (2001) Dynamic copy choice: Steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching. Proc. Natl. Acad. Sci. USA 98:12209-12214. [Abstract] [Full-text PDF article] Hu,
W.-S., and Pathak, V.K. (2000) Design of retroviral vectors and helper
cells for gene therapy. Pharmacol. Rev. 52: 493-511. [Abstract] [Full-text
PDF
article] Halvas, E.K., Svarovskaia, E.S., and Pathak, V.K. (2000) Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity. J. Virol. 74: 10349-10358. [Abstract] [Full-text PDF article] Svarovskaia,
E.S., Delviks, K.A., Hwang, C.K., and Pathak, V.K. (2000) Structural determinants
of murine leukemia virus reverse transcriptase that affect the frequency of template
switching. J. Virol. 74: 7171-7178. [Abstract] [Full-text
PDF article] Halvas, E.K., Svarovskaia,
E.S., Freed, E.O., and Pathak, V.K. (2000) Wild-type and YMDD mutant murine
leukemia virus reverse transcriptases are resistant to 2’,3’-dideoxy-3’-thiacytidine.
J. Virol. 74: 6669-6674. [Abstract] [Full-text
PDF article] Halvas, E.K., Svarovskaia,
E.S., and Pathak, V.K. (2000) Development of an in vivo assay to identify
structural determinants in murine leukemia virus reverse transcriptase important
for fidelity. J. Virol. 74: 312-319. [Abstract] [Full-text
PDF article] Delviks, K.D., and Pathak,
V.K. (1999) Development of murine leukemia virus-based self-activating vectors
that efficiently delete the selectable drug resistance gene during reverse transcription.
J. Virol. 73: 8837-8842. [Abstract] [Full-text
PDF article] Delviks,
K.D., and Pathak, V.K. (1999) Effect of distance between homologous sequences
and 3' homology on the frequency of retroviral reverse transcriptase template
switching. J. Virol. 73: 7923-7932. [Abstract] [Full-text
PDF article] Pathak, V.K., and Hu, W.-S. (1998) Mutation, recombination, and dynamics of HIV-1 in vivo. In: Human Immunodeficiency Viruses: Biology, Immunology, and Molecular Biology (Nitin Saksena, Ed.), Medical Systems SpA, pp. 299-330. Julias,
J.G., and Pathak, V.K. (1998) Deoxyribonucleoside triphosphate pool imbalances
in vivo are associated with an increased retroviral mutation rate. J. Virol. 72:
7941-7949. Hu, W.-S., Bowman, E.H., Delviks, K.A., and Pathak, V.K. (1997) Homologous recombination occurs in a distinct retroviral subpopulation and exhibits high negative interference. J. Virol. 71: 6028-6036. [Abstract] [Full-text PDF article] | ... |