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Head,
RT Biochemistry Section, HIV DRP,
and Head, Center of Excellence in HIV/AIDS
& Cancer Virology, CCR
HIV
Drug Resistance Program
National Cancer Institute
NCI-Frederick, P.O. Box
B, Building 535
Frederick, MD 21702-1201
Phone: 301-846-5256
Fax:
301-846-6013
E-mail: slegrice@ncifcrf.gov
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Dr. Le Grice received his Ph.D. from the Department of Biochemistry, University
of Manchester, UK, in 1976, where he studied the mechanisms of R-factor-mediated
multidrug resistance in Escherichia coli. After postdoctoral training
in the United Kingdom, Germany, and the United States, he was appointed Senior
Scientist in the Central Research Units of Hoffmann La Roche, Basel, Switzerland,
where he worked from 1984 to 1990 evaluating HIV-1 and HIV-2 enzymes as therapeutic
targets. In 1990, he joined the faculty in the Division of Infectious Diseases,
Department of Medicine, Case Western Reserve University (CWRU), Cleveland, OH.
Initially recruited as an Associate Professor of Medicine, he was awarded tenure
in 1992, and in 1995 was promoted to Professor of Medicine, Biochemistry, and
Oncology. From 1994 to 1999, he served as Director of the NIH-funded CWRU
Center for AIDS Research. Dr. Le Grice joined the National Cancer Institute
in 1999 as Chief of the Resistance Mechanisms Laboratory in the HIV Drug Resistance
Program, Center for Cancer Research (CCR), and in 2005 was appointed to the Senior
Biomedical Research Service. In 2006, he was appointed Head of the Center
of Excellence in HIV/AIDS & Cancer Virology, CCR. He is a member of
the CCR HIV and Cancer Virology faculty, Chemistry and Biology faculty, and the
Steering Committee of the Molecular Targets Discovery Program. In addition
to serving on the Editorial Board of the Journal of Biological Chemistry, Dr.
Le Grice has been an ad hoc (1990-1999) and permanent Study Section member of
NIH AIDS review panels (2000-2004), as well as an ad hoc reviewer for several
international funding agencies.
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