Vineet N. KewalRamani, Ph.D.Link to KewalRamani home pageLink to KewalRamani research pageLink to KewalRamani publications pageLink to KewalRamani staff page
... Skip navigation links
Link to home page of HIV Drug Resistance Program website
Link to Mission, HIV Drug Resistance Program, National Cancer Institute
Link to News & Events, HIV Drug Resistance Program, National Cancer Institute
Link to Research Team, HIV Drug Resistance Program, National Cancer Institute
Link to Clinical Trials, HIV Drug Resistance Program, National Cancer Institute
Link to Recruitment, HIV Drug Resistance Program, National Cancer Institute
Link to Resources, HIV Drug Resistance Program, National Cancer Institute
Link to Related Sites, HIV Drug Resistance Program, National Cancer Institute
Link to Staff Directory, HIV Drug Resistance Program, National Cancer Institute

Link to National Cancer Institute - external website
Link to National Cancer Institute at Frederick - external website
...

Full PubMed List of Publications by V.N. KewalRamani


Selected Publications by the Model Development Section

* Highly cited (30 or more citations)

Maertens, G.N., Cook, N.J., Wang, W., Hare, S., Gupta, S.S., Oztop, I., Lee, K., Pye, V.E., Cosnefroy, O., Snijders, A.P., KewalRamani, V.N., Fassati, A., Engelman, A., and Cherepanov, P.  (2014)  Structural basis for nuclear import of splicing factors by human Transportin 3.     Proc. Natl. Acad. Sci. USA 111: 2728-2733.     [Abstract]     
[Full-text PDF (1552 K) from NIH Public Access]     [Supporting information]
[PMID: 24449914; PMCID: PMC3932936]

Koh, Y., Wu, X., Ferris, A.L., Matreyek, K.A., Smith, S.J., Lee, K., KewalRamani, V.N., Hughes, S.H., and Engelman, A.  (2013)  Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration.  J. Virol. 87: 648-658.
[Abstract]     [Full-text PDF article - 1818 K]

Afonin, K.A., Desai, R., Viard, M., Kireeva, M.L., Bindewald, E., Case, C.L., Maciag, A.E., Kasprzak, W.K., Kim, T., Sappe, A., Stepler, M., Kewalramani, V.N., Kashlev, M., Blumenthal, R., and Shapiro, B.A.  (2013)  Co-transcriptional production of RNA-DNA hybrids for simultaneous release of multiple split functionalities.  Nucleic Acids Res. 42: 2085-2097.
[Abstract]     [Full-text PDF article - 11,098 K]

Price, A.J., Fletcher, A.J., Schaller, T., Elliott, T., Lee, K., KewalRamani, V.N., Chin, J.W., Towers, G.J., and James, L.C.  (2012)  CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.  PLoS Pathog. 8(8): e1002896.
[Abstract]     [Full-text PDF article - 4085 K]

Ambrose, Z., Lee, K., Ndjomou, J., Xu, H., Oztop, I., Matous, J., Takemura, T., Unutmaz, D., Engelman, A., Hughes, S.H., and KewalRamani, V.N.  (2012)  Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.  J. Virol. 86: 4708-4714.      [Abstract]     [Full-text PDF article - 1244 K]

Lee, K., Mulky, A., Yuen, W., Martin, T.D., Meyerson, N.R., Choi, L., Yu, H., Sawyer, S.L., and KewalRamani, V.N.  (2012)  HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6.  J. Virol. 86: 3851-3860.
[Abstract]     [Full-text PDF article - 2228 K]     [Supplemental material]

* Schaller, T., Ocwieja, K.E., Rasaiyaah, J., Price, A.J., Brady, T.L., Roth, S.L., Hué, S., Fletcher, A.J., Lee, K., KewalRamani, V.N., Noursadeghi, M., Jenner, R.G., James, L.C., Bushman, F.D., and Towers, G.J.  (2011)  HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.  PLoS Pathog. 7: e1002439.     [Abstract]     [Full-text PDF article - 1723 K]

Kearney, M., Spindler, J., Shao, W., Maldarelli, F., Palmer, S., Hu, S.L., Lifson, J.D., KewalRamani, V.N., Mellors, J.W., Coffin, J.M., and Ambrose, Z.  (2011)  Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy.  J. Virol. 85: 1067-1076.
[Abstract]     [Full-text PDF article - 1165 K]

* Lee, K., Ambrose, Z., Martin, T.D., Oztop, I., Mulky, A., Julias, J.G., Vandegraaff, N., Baumann, J.G., Wang, R., Yuen, W., Takemura, T., Shelton, K., Taniuchi, I., Li, Y., Sodroski, J., Littman, D.R., Coffin, J.M., Hughes, S.H., Unutmaz, D., Engelman, A., and KewalRamani, V.N.  (2010)  Flexible use of nuclear import pathways by HIV-1.  Cell Host Microbe 7: 221-233.
[Abstract]     [Full-text PDF article - 1269 K]     [Cover]
[Supplemental information - 3601 K PDF]

* Furtak, V., Mulky, A., Rawlings, S.A., Kozhaya, L., Lee, K., KewalRamani, V.N., and Unutmaz, D.  (2010)  Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.  PLoS ONE 5: e9081.     [Abstract]     [Full-text PDF article - 856 K]

Chung, N.P.Y., Breun, S.K.J., Bashirova, A., Baumann, J.G., Martin, T.D., Karamchandani, J.M., Rausch, J.W., Le Grice, S.F.J., Wu, L., Carrington, M., and KewalRamani, V.N.  (2010)  HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).  J. Biol. Chem. 285: 2100-2112.
[Abstract]     [Full-text PDF article - 3786 K]     [Supplemental data - 469 K PDF]

* Krishnan, L., Matreyek, K.A., Oztop, I., Lee, K., Tipper, C.H., Li, X., Dar, M.J., KewalRamani, V.N., and Engelman, A.  (2010)  The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.  J. Virol. 84: 397-406.     [Abstract]     [Full-text PDF article - 3263 K]

* Hatziioannou, T., Ambrose, Z., Chung, N.P.Y., Piatak, M., Jr., Yuan, F., Trubey, C.M., Coalter, V., Kiser, R., Schneider, D., Smedley, J., Pung, R., Gathuka, M., Estes, J.D., Veazey, R.S., KewalRamani, V.N., Lifson, J.D., and Bieniasz, P.D.  (2009)  A macaque model of HIV-1 infection.  Proc. Natl. Acad. Sci. USA 106: 4425-4429.
[Abstract]     [Full-text PDF article - 689 K]
[PNAS online supporting information related to this article - 385 K PDF]

Shao, W., Kearney, M., Maldarelli, F., Mellors, J.W., Stephens, R.M., Lifson, J.D., KewalRamani, V.N., Ambrose, Z., Coffin, J.M., and Palmer, S.E.  (2009)  RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.  Retrovirology 6: 101.      [Abstract]     [Full-text PDF article - 1832 K]

Ambrose, Z., Compton, L., Piatak, M., Jr., Lu, D., Alvord, W.G., Lubomirski, M.S., Hildreth, J.E.K., Lifson, J.D., Miller, C.J., and KewalRamani, V.N.  (2008)  Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.  J. Virol. 82: 6591-6599.
[Abstract]     [Full-text PDF article]

Mulky, A., Cohen, T.V., Kozlov, S.V., Korbei, B., Foisner, R., Stewart, C.L., and KewalRamani, V.N.  (2008)  The LEM domain proteins emerin and LAP2a are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections.  J. Virol. 82: 5860-5868.     [Abstract]     [Full-text PDF article]

Ambrose, Z., Palmer, S., Boltz, V.F., Kearney, M., Larsen, K., Polacino, P., Flanary, L., Oswald, K., Piatak, M., Jr., Smedley, J., Shao, W., Bischofberger, N., Maldarelli, F., Kimata, J.T., Mellors, J.W., Hu, S.-L., Coffin, J.M., Lifson, J.D., and KewalRamani, V.N.  (2007)  Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.  J. Virol. 81: 12145-12155.
[Abstract]     [Full-text PDF article]

* Ambrose, Z., KewalRamani, V.N., Bieniasz, P.D., and Hatziioannou, T.  (2007)  HIV/AIDS: In search of an animal model.  Trends Biotechnol. 25: 333-337.
[Abstract]     [Full-text PDF article]

* Wang, J.-H., Janas, A.M., Olson, W.J., KewalRamani, V.N., and Wu, L.  (2007)  CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1.  J. Virol. 81: 2497-2507.     [Abstract]     [Full-text PDF article]

* Wu, L., and KewalRamani, V.N.  (2006)  Dendritic-cell interactions with HIV: Infection and viral dissemination.  Nat. Rev. Immun. 6: 859-868.     [Abstract]     [Full-text PDF article]

Ambrose, Z., Julias, J.G., KewalRamani, V.N., and Hughes, S.H.  (2006)  The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine.  J. Virol. 80: 2578-2581.
[Abstract]     [Full-text PDF article]

Garcia-Pineres, A.J., Hildesheim, A., Trivett, M., Williams, M., Wu, L., KewalRamani, V.N., and Pinto, L.A.  (2006)  Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine.  Eur. J. Immunol. 36: 437-445.
[Abstract]     [Full-text PDF article]

* VanCompernolle, S.E., Taylor, R.J., Oswald-Richter, K., Jiang, J., Youree, B.E., Bowie, J.H., Tyler, M.J., Conlon, J.M., Wade, D., Aiken, C., Dermody, T.S., KewalRamani, V.N., Rollins-Smith, L.A., and Unutmaz, D.  (2005)  Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.  J. Virol. 79: 11598-11606.     [Abstract]     [Full-text PDF article]

* Dang, Q., Chen, J., Unutmaz, D., Coffin, J.M., Pathak, V.K., Powell, D., KewalRamani, V.N., Maldarelli, F., and Hu, W.-S.  (2004)  Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways.  Proc. Natl. Acad. Sci. USA 101: 632-637.     [Abstract]     [Full-text PDF article]
[Supporting text]

* Ambrose, Z., Boltz, V., Palmer, S., Coffin, J.M., Hughes, S.H., and KewalRamani, V.N.  (2004)  In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.  J. Virol. 78: 13553-13561.     [Abstract]     [Full-text PDF article]

* Baumann, J.G., Unutmaz, D., Miller, M.D., Breun, S.K.J., Grill, S.M., Mirro, J., Littman, D.R., Rein, A., and KewalRamani, V.N.  (2004)  Murine T cells potently restrict human immunodeficiency virus infection.  J. Virol. 78: 12537-12547.
[Abstract]     [Full-text PDF article]

Lee, K., and KewalRamani, V.N.  (2004)  In defense of the cell: TRIM5a interception of mammalian retroviruses.  Proc. Natl. Acad. Sci. USA 101: 10496-10497.
[PubMed citation]     [Full-text PDF article]

Wu, L., Martin, T.D., Han, Y.-C., Breun, S.K.J., and KewalRamani, V.N.  (2004)  Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission.  Retrovirology 1: 14 (Epub).     [PubMed citation]     [Full-text PDF article]

* Wu, L., Martin, T.D., Carrington, M., and KewalRamani, V.N.  (2004)  Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.  Virology 318: 17-23.
[Abstract]     [Full-text PDF article]

Rawat, S.S., Eaton, J., Gallo, S.A., Martin, T.D., Ablan, S., Ratnayake, S., Viard, M., KewalRamani, V.N., Wang, J.M., Blumenthal, R., and Puri, A.  (2004)  Functional expression of CD4, CXCR4, and CCR5 in glycosphingolipid-deficient mouse melanoma GM95 cells and susceptibility to HIV-1 envelope glycoprotein-triggered membrane fusion.  Virology 318: 55-65.
[Abstract]     [Full-text PDF article]

Rawat, S.S., Gallo, S.A., Eaton, J., Martin, T.D., Ablan, S., KewalRamani, V.N., Wang, J.M., Blumenthal, R., and Puri A.  (2004)  Elevated expression of GM3 in receptor-bearing targets confers resistance to human immunodeficiency virus type 1 fusion.  J. Virol. 78: 7360-7368.  [Abstract]     [Full-text PDF article]

KewalRamani, V.N., and Coffin, J.M.  (2003)  Weapons of mutational destruction.  Science 301: 923-925.      [PubMed citation]     [Full-text PDF article]

* McDonald, D., Wu, L., Bohks, S.M., KewalRamani, V.N., Unutmaz, D., and Hope, T.J.  (2003)  Recruitment of HIV and its receptors to dendritic cell-T cell junctions.  Science 300: 1295-1297.
[Abstract]     [Full-text PDF article]

* Bashirova, A.A., Wu, L., Cheng, J., Martin, T.D., Martin, M.P., Benveniste, R.E., Lifson, J.D., KewalRamani, V.N., Hughes, A., and Carrington, M. (2003) Novel member of the CD209 (DC-SIGN) gene family in primates. J. Virol. 77: 217-227.     [Abstract]     [Full-text PDF article]

* Wu, L., Martin, T.D., Vazeux, R., Unutmaz, D., and KewalRamani, V.N.  (2002)  Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission.  J. Virol. 76: 5905-5914.
[Abstract]     [Full-text PDF article]

* Wu, L., Bashirova, A.A., Martin, T.D., Villamide, L., Mehlhop, E., Chertov, A.O., Unutmaz, D., Pope, M., Carrington, M., and KewalRamani, V.N.  (2002)  Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN.  Proc. Natl. Acad. Sci. USA 99:1568-1573.     [Abstract]     [Full-text PDF article]

* Bashirova, A.A., Geijtenbeek, T.B., van Duijnhoven, G.C., van Vliet, S.J., Eilering, J.B., Martin, M.P., Wu, L., Martin, T.D., Viebig, N., Knolle, P.A., KewalRamani, V.N., van Kooyk, Y., and Carrington, M.  (2001)  A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.  J. Exp. Med. 193:671-678.
[Abstract]     [Full-text PDF article]

* Geijtenbeek, T.B., Kwon, D.S., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C., Middel, J., Cornelissen, I.L., Nottet, H.S., KewalRamani, V.N., Littman, D.R., Figdor, C.G., and van Kooyk, Y.  (2000)  DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.  Cell 100: 587-597.     [Abstract]     [Full-text PDF article]

* Unutmaz, D., KewalRamani, V.N., Marmon, S., and Littman, D.R.  (1999)  Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes.  J. Exp. Med. 189: 1735-1746.     [Abstract]     [Full-text PDF article+]

* Garber, M.E., Wei, P., KewalRamani, V.N., Mayall, T.P., Herrmann, C.H., Rice, A.P., Littman, D.R., and Jones, K.A.  (1998)  The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.  Genes Dev. 12: 3512-3527.
[Abstract]     [Full-text PDF article§]

* Cecilia, D., KewalRamani, V.N., O'Leary, J., Volsky, B., Nyambi, P., Burda, S., Xu, S., Littman, D.R., and Zolla-Pazner, S. (1998) Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usage. J. Virol. 72: 6988-6996.     [Abstract]     [Full-text PDF article]

* Deng, H.-K., Unutmaz, D., KewalRamani, V.N., and Littman, D.R.  (1997)  Expression cloning of new receptors used by simian and human immunodeficiency viruses.  Nature 388: 296-300.     [Abstract]     [Full-text PDF article]

* KewalRamani, V.N., and Emerman, M.  (1996)  Vpx association with mature core structures of HIV-2.  Virology 218: 159-168.     [Abstract]     [Full-text PDF article]

* KewalRamani, V.N., Panganiban, A.T., and Emerman, M.  (1992)  Spleen necrosis virus, an avian immunosuppressive retrovirus, shares a receptor with the type D simian retroviruses.  J. Virol. 66: 3026-3031.     [Abstract]     [Full-text PDF article]


+ Reproduced from The Journal of Experimental Medicine, 1999, Vol. 189, pp. 1735-1746 by copyright permission of The Rockefeller University Press.

§ Permission was granted from Cold Spring Harbor Laboratory Press to copy this PDF article and link it directly on this website.

Last modified: 22 April 2014

...



HIV DRP Home
Mission | News & Events | Research Team | Clinical Trials | Recruitment | Resources
Related Sites | Staff Directory | NCI Home | NCI at Frederick | Site Map | Disclaimers & Policies | Contact Us

Accessibility | Viewing Files

National Cancer Institute logo     Health and Human Services logo National Institutes of Health logo Logo of USA.gov official web portal