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Bauman, J., Das, K., Ho, W., Baweja, M., Himmel, D., Clark, A., Oren, D., Boyer, P.L., Hughes, S.H., Shatkin, A., and Arnold, E. (2008) Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res., in press. Delviks-Frankenberry, K.A., Nikolenko, G.N., Boyer, P.L., Hughes, S.H., Coffin, J.M., Jere, A., and Pathak, V.K. (2008) HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. Proc. Natl. Acad. Sci. USA, in press. Das, K., Clark, A.D., Lewi, P., Hughes, S.H., and Arnold, E. (2008) Detection of non-nucleoside inhibitor binding to HIV-1 reverse transcriptase by dynamic light scattering. Biophys. J., in press. Hu,
J., Renaud, G., Golmes, T., Ferris, A., Hendrie, P.C., Donahue, R.E., Hughes,
S.H., Wolfsberg, T.G., Russell, D.W., and Dunbar, C.E. (2008)
Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term
repopulating cells compared to standard murine retrovirus vectors. Mol.
Ther., in press (June 24 Epub ahead of print). Chang, K.W., Oh, J., Alvord, W.G., and Hughes, S.H. (2008) The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase. J. Virol., in press (June 18 Epub ahead of print). [Abstract] [Full-text PDF article] Comin, M.J., Vu, B.C., Boyer, P.L., Liao, C., Hughes, S.H., and Marquez, V.E. (2008) D-(+)-iso-methanocarbathymidine, a high-affinity substrate for herpes simplex virus 1 thymidine kinase. ChemMedChem 3: 1129-1134. [Abstract] [Full-text PDF article] McWilliams, M.J., Julias, J.G., and Hughes, S.H. (2008) Mutations in the human immunodeficiency virus type 1 polypurine tract (PPT) reduce the rate of PPT cleavage and plus-strand DNA synthesis. J. Virol. 82: 5104-5108. [Abstract] [Full-text PDF article] Sheng,
L., Cai, F., Zhu, Y., Pal, A., Athanasiou, M., Orrison, B., Blair, D.G., Hughes,
S.H., Coffin, J.M., Lewis, A.M., and Peden, K. (2008) Oncogenicity
of DNA in vivo: Tumor induction with expression plasmids for activated
H-ras and c-myc. Biologicals 36: 184-197. Gao,
L., Hanson, M.N., Balakrishnan, M., Boyer, P.L., Roques, B.P., Hughes, S.H.,
Kim, B., and Bambara, R.A. (2008) Apparent defects in processive DNA
synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1
reverse transcriptase derive solely from a dNTP utilization defect. J. Biol.
Chem. 283: 9196-9205. Das, K., Bauman, J.D., Clark, A.D., Jr., Frenkel, Y.V., Lewi, P.J., Shatkin, A.J., Hughes, S.H., and Arnold, E. (2008) High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations. Proc. Natl. Acad. Sci. USA 105: 1466-1471. [Abstract] [Full-text PDF article] Zhao, X.Z., Semenova, E.A., Vu, B.C., Maddali, K., Marchand, C., Hughes, S.H., Pommier, Y., and Burke, T.R., Jr. (2008) 2,3-Dihydro-6,7-dihydroxy-1H-isoindol-1-one based HIV-1 integrase inhibitors. J. Med. Chem. 51: 251-259. [Abstract] [Full-text PDF article] Oh, J., McWilliams, M.J., Julias, J.G., and Hughes, S.H. (2008) Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo. J. Virol. 82: 719-727. [Abstract] [Full-text PDF article] Oh,
J., Chang, K.W., Wierzchoslawski, R., Alvord, W.G., and Hughes, S.H.
(2008) Rous sarcoma virus (RSV) integration in vivo: A CA dinucleotide is
not required in U3, and RSV linear DNA does not autointegrate. J. Virol.
82: 503-512. Hughes, S.H., and Crise, B. (2007) Using viral vectors in animal research. In Richmond, J.Y. (ed.), Anthology of Biosafety: X, Animal Biosafety, American Biological Safety Association, pp. 145-166. Wu, C.-K., Gousset, K., and Hughes, S.H. (2007) Targeting to the endoplasmic reticulum improves the folding of recombinant human telomerase reverse transcriptase. Prot. Expr. Purif. 56: 8-19. [Abstract] [Full-text PDF article] Boyer, P.L., Stenbak, C.R., Hoberman, D., Linial, M.L., and Hughes, S.H. (2007) In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT. Virology 367: 253-264. [Abstract] [Full-text PDF article] Morningstar, M.L., Roth, T., Farnsworth, D.W., Kroeger Smith, M., Watson, K., Buckheit, R.W., Jr., Das, K., Zhang, W., Arnold, E., Julias, J.G., Hughes, S.H., and Michejda, C.J. (2007) Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme. J. Med. Chem. 50: 4003-4015. [Abstract] [Full-text PDF article] Boyer, P.L., Julias, J.G., Ambrose, Z., Siddiqui, M.A., Marquez, V.E., and Hughes, S.H. (2007) The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants. J. Mol. Biol. 371: 873-882. [Abstract] [Full-text PDF article] Hu,
J., Ferris, A., Larochelle, A., Krouse, A.E., Metzger, M.E., Donahue, R.E., Hughes,
S.H., and Dunbar, C.E. (2007) Transduction of rhesus macaque hematopoietic
stem and progenitor cells with avian sarcoma and leukosis viral vectors.
Human Gene Ther. 18: 691-700. Derse, D., Crise, B., Li, Y., Princler, G., Lum, N., Stewart, C., McGrath, C.F., Hughes, S.H., Munroe, D.J., and Wu, X. (2007) Human T-cell leukemia virus type 1 integration target sites in the human genome: Comparison with those of other retroviruses. J. Virol. 81: 6731-6741. [Abstract] [Full-text PDF article] Jones, F.D., and Hughes, S.H. (2007) In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity. Virology 360: 341-349. [Abstract] [Full-text PDF article] Das, K., Sarafianos, S.G., Clark, A.D., Jr., Boyer, P.L., Hughes, S.H., and Arnold, E. (2007) Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. J. Mol. Biol. 365: 77-89. [Abstract] [Full-text PDF article] Mulky,
A., Vu, B.C., Conway, J.A., Hughes, S.H., and Kappes, J.C. (2007)
Analysis of amino acids in the b7-b8
loop of human immunodefiency virus type 1 reverse transcriptase for their role
in virus replication. J. Mol. Biol. 365: 1368-1378. Himmel, D.M., Sarafianos, S.G., Dharmasena, S., Hossain, M.M., McCoy-Simandle, K., Ilina, T., Clark, A.D., Jr., Knight, J.L., Julias, J.G., Clark, P.K., Krogh-Jespersen, K., Levy, R.M., Hughes, S.H., Parniak, M.A., and Arnold, E. (2006) HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. ACS Chem. Biol. 1: 702-712. [Abstract] Garfinkel, D.J., Stefanisko, K.M., Nyswaner, K.M., Moore, S.P., Oh, J., and Hughes, S.H. (2006) Retrotransposon suicide: Formation of Ty1 circles and autointegration via a central DNA flap. J. Virol. 80: 11920-11934. [Abstract] [Full-text PDF article] Oh,
J., Chang, K.W., and Hughes, S.H. (2006) Alternate polypurine
tracts affect Rous sarcoma virus integration in vivo. J. Virol. 80: 10281-10284. Marquez,
V.E., Hughes, S.H., Sei, S., and Agbaria, R. (2006) The history
of N-methanocarbathymidine: The investigation of a conformational concept
leads to the discovery of a potent and selective nucleoside antiviral agent.
Antiviral Res. 71: 268-275. McWilliams, M.J., Julias, J.G., Sarafianos, S.G., Alvord, W.G., Arnold, E., and Hughes, S.H. (2006) Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization. Virology 348: 378-388. [Abstract] [Full-text PDF article] Boyer,
P.L., Sarafianos, S.G., Arnold, E., and Hughes, S.H. (2006)
Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?
PLoS Pathogens 2(2):e10. Ambrose,
Z., Julias, J.G., KewalRamani, V.N., and Hughes, S.H. (2006)
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1
particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine.
J. Virol. 80: 2578-2581. Oh,
J., Chang, K.W., and Hughes, S.H. (2006) Mutations in the U5
sequences adjacent to the primer binding site do not affect tRNA cleavage by Rous
sarcoma virus RNase H but do cause aberrant integrations in vivo. J. Virol.
80: 451-459. Himmel,
D.M., Das, K., Clark, A.D., Jr., Hughes, S.H., Benjahad, A., Oumouch, S.,
Guillemont, J., Coupa, S., Poncelet, A., Csoka, I., Meyer, C., Andries, K., Nguyen,
C.H., Grierson, D.S., and Arnold, E. (2005) Crystal structures for
HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A
new class of non-nucleoside inhibitors effective against a broad range of drug-resistant
strains. J. Med. Chem. 48: 7582-7591. Chang, K.W., Julias, J.G., Alvord, W.G., Oh, J., and Hughes, S.H. (2005) Alternate polypurine tracts (PPTs) affect the Rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction. J. Virol. 79: 13694-13704. [Abstract] [Full-text PDF article] Hughes, S.H. (2005) Wiggling and jiggling can increase the effectiveness of AIDS drugs. Frontiers in Science 4: 7-8. [Full-text PDF article] Chang,
K.W., Barsov, E.V., Ferris, A.L., and Hughes, S.H. (2005) Mutations
of a residue within the polypurine-rich region of Env alter the replication rate
and level of cytopathic effects in chimeric avian retroviral vectors. J.
Virol. 79: 10258-10267. Janssen,
P.A.J., Lewi, P.J., Arnold, E., Daeyaert, F., de Jonge, M., Heeres, J., Koymans,
L., Vinkers, M., Guillemont, J., Pasquier, E., Kukla, M., Ludovici, D., Andries,
K., de Béthune, M.-P., Pauwels, R., Das, K., Clark, A.D., Jr., Frenkel, Y.V.,
Hughes, S.H., Medaer, B., De Knaep, F., Bohets, H., De Clerck, F., Lampo,
A., Williams, P., and Stoffels, P. (2005) In search of a novel anti-HIV
drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
(R278474, rilpivirine). J. Med. Chem. 48: 1901-1909. Das, K., Lewi, P.J., Hughes, S.H., and Arnold, E. (2005) Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors. Prog. Biophys. Mol. Biol. 88: 209-231. [Abstract] [Full-text PDF article] Boyer, P.L., Julias, J.G., Marquez, V.E., and Hughes, S.H. (2005) Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases. J. Mol. Biol. 345: 441-450. [Abstract] [Full-text PDF article] Sarafianos, S.G., Das, K., Hughes, S.H., and Arnold, E. (2004) Taking aim at a moving target: Designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases. Curr. Topics Struct. Biol. 14: 716-730. [Abstract] [Full-text PDF article] Ambrose, Z., Boltz, V., Palmer, S., Coffin, J.M., Hughes, S.H., and KewalRamani, V.N. (2004) In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques. J. Virol. 78: 13553-13561. [Abstract] [Full-text PDF article] Julias,
J.G., McWilliams, M.J., Sarafianos, S.G., Alvord, W.G., Arnold, E., and Hughes,
S.H. (2004) Effects of mutations in the G tract of the human immunodeficiency
virus type 1 polypurine tract on virus replication and RNase H cleavage.
J. Virol. 78: 13315-13324. Siddiqui, M.A., Hughes, S.H., Boyer, P.L., Mitsuya, H., Van, Q.N., George, C., Sarafianos, S.G., and Marquez, V.E. (2004) A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides. J. Med. Chem. 47: 5041-5045. [Abstract] [Full-text PDF article] Hughes,
S.H. (2004) The RCAS vector system. Folia Biologica 50:
107-119. Boyer,
P.L., Imamichi, T., Sarafianos, S.G., Arnold, E., and Hughes, S.H.
(2004) Effects of the delta 67 complex of mutations in human immunodeficiency
virus type 1 reverse transcriptase on nucleotide analog excision. J. Virol.
78: 9987-9997. Kvaratskhelia, M., Clark, P.K., Hess, S., Melder, D.C., Federspiel, M.J., and Hughes, S.H. (2004) Identification of glycosylation sites in the SU component of the avian sarcoma/leukosis virus envelope glycoprotein (subgroup A) by mass spectrometry. Virology 326: 171-181. [Abstract] [Full-text PDF article] Sarafianos, S.G., Hughes, S.H., and Arnold, E. (2004) Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs. Int. J. Biochem. Cell Biol. 36: 1706-1715. [Abstract] [Full-text PDF article] Boyer, P.L., Stenbak, C.R., Clark, P.K., Linial, M.L., and Hughes, S.H. (2004) Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase. J. Virol. 78: 6112-6121. [Abstract] [Full-text PDF article] Tuske,
S., Sarafianos, S.G., Clark, A.D., Ding, J., Naeger, L.K., White, K.L., Miller,
M.D., Gibbs, C.S., Boyer, P.L., Clark, P., Wang, G., Gaffney, B.L., Jones, R.A.,
Jerina, D.M., Hughes, S.H., and Arnold, E. (2004) Structures
of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug
tenofovir. Nat. Struct. Mol. Biol. 11: 467-474. Das,
K., Clark, A.D., Jr., Lewi, P.J., Heeres, J., de Jonge, M.R., Koymans, L.M.H.,
Vinkers, H.M., Daeyaert, F., Ludovici, D.W., Kukla, M.J., De Corte, B., Kavash,
R.W., Ho, C.Y., Ye, H., Lichtenstein, M.A., Andries, K., Pauwels, R., de Bethune,
M.-P., Boyer, P.L., Clark, P., Hughes, S.H., Janssen, P.A.J., and Arnold,
E. (2004) Roles of conformational and positional adaptability in structure-based
design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase
inhibitors that are highly potent and effective against wild-type and drug-resistant
HIV-1 variants. J. Med. Chem. 47: 2550-2560. Julias,
J.G., Boyer, P.L., McWilliams, M.J., Alvord, W.G., and Hughes, S.H.
(2004) Mutations at position 184 of human immunodeficiency virus type-1
reverse transcriptase affect virus titer and viral DNA synthesis. Virology
322: 13-21. Peletskaya,
E.N., Kogon, A.A., Tuske, S., Arnold, E., and Hughes, S.H. (2004)
Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain
of human immunodeficiency virus type 1 reverse transcriptase with DNA. J.
Virol. 78: 3387-3397. Sismour,
A.M., Lutz, S., Park, J.H., Lutz, M.J., Boyer, P.L., Hughes, S.H., and
Benner, S.A. (2004) PCR amplification of DNA containing non-standard
base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1.
Nucleic Acids Res. 32: 728-735. Princler,
G.L., Julias, J.G., Hughes, S.H., and Derse, D. (2003) Roles
of viral and cellular proteins in the expression of alternatively spliced HTLV-1
pX mRNAs. Virology 317: 136-145. Kroeger
Smith, M.B., Ruby, S., Horouzhenko, S., Buckingham, B., Richardson, J., Puleri,
I., Potts, E., Jorgensen, W.L., Arnold, E., Zhang, W., Hughes, S.H., Michejda,
C.J., and Smith, R.H., Jr. (2003) HIV-1 reverse transcriptase variants:
Molecular modeling of Y181C, V106A, L100I, and K103N mutations with nonnucleoside
inhibitors using Monte Carlo simulations in combination with a linear response
method. Drug Des. Discov. 18: 151-163. [Abstract]
McWilliams,
M.J., Julias, J.G., Sarafianos, S.G., Alvord, W.G., Arnold, E., and Hughes,
S.H. (2003) Mutations in the 5' end of the human immunodeficiency
virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer.
J. Virol. 77: 11150-11157. Lewi,
P.J., de Jonge, M., Daeyaert, F., Koymans, L., Vinkers, M., Heeres, J., Janssen,
P.A., Arnold, E., Das, K., Clark, A.D., Jr., Hughes, S.H., Boyer, P.L.,
de Bethune, M.P., Pauwels, R., Andries, K., Kukla, M., Ludovici, D., De Corte,
B., Kavash, R., and Ho, C. (2003) On the detection of multiple-binding
modes of ligands to proteins, from biological, structural, and modeling data.
J. Comput. Aided. Mol. Des. 17: 129-134. Choi,
Y., George, C., Comin, M.J., Barchi, J.J. Jr., Kim, H.S., Jacobson, K.A., Balzarini,
J., Mitsuya, H., Boyer, P.L., Hughes, S.H., and Marquez, V.E. (2003)
A conformationally locked analogue of the anti-HIV agent stavudine. An important
correlation between pseudorotation and maximum amplitude. J. Med. Chem.
46: 3292-3299. Julias,
J.G., McWilliams, M.J., Sarafianos, S.G., Alvord, W.G., Arnold, E., and Hughes,
S.H. (2003) Mutation of amino acids in the connection domain of
human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer
affects RNase H activity. J. Virol. 77: 8548-8554.
[Abstract] [Full-text
PDF article]
Golinelli,
M.-P., and Hughes, S.H. (2003) Secondary structure in the nucleic
acid affects the rate of HIV-1 nucleocapsid-mediated strand annealing. Biochemistry
42: 8153-8162. Kroeger
Smith, M.B., Hose, B.M., Hawkins, A., Lipchock, J., Farnsworth, D.W., Rizzo, R.C.,
Tirado-Rives, J., Arnold, E., Zhang, W., Hughes, S.H., Jorgensen, W.L.,
Michejda, C.J., and Smith, R.H., Jr. (2003) Molecular modeling calculations
of HIV-1 reverse transcriptase nonnucleoside inhibitors: Correlation of binding
energy with biological activity for novel 2-aryl-substituted benzimidazole analogues.
J. Med. Chem. 46: 1940-1947. Sarafianos,
S.G., Clark, A.D., Jr., Tuske, S., Squire, C.J., Das, K., Sheng, D., Ilankumaran,
P., Ramesha, A.R., Kroth, H., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes,
S.H., and Arnold, E. (2003) Trapping HIV-1 reverse transcriptase
before and after translocation on DNA. J. Biol. Chem. 278: 16280-16288. [Abstract] [Full-text
PDF article]
Skillman,
A.G., Maurer, K.W., Roe, D.C., Stauber, M.J., Eargle, D., Ewing, T.J.A., Muscate,
A., Davioud-Charvet, E., Medaglia, M.V., Fisher, R.J., Arnold, E., Gao, H.-Q.,
Buckheit, R., Boyer, P.L., Hughes, S.H., Kuntz, I.D., and Kenyon, G.L.
(2002) A novel mechanism for inhibition of HIV-1 reverse transcriptase.
Bioorg. Chem. 30: 443-458. Sarafianos,
S.G., Clark, A.D., Jr., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, P., Ramesha,
A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., and Arnold,
E. (2002) Structures of HIV-1 reverse transcriptase with pre- and
post-translocation AZTMP-terminated DNA. EMBO J. 21: 6614-6624. [Abstract] [Full-text
PDF
article] Boyer,
P.L., Sarafianos, S.G., Arnold, E., and Hughes, S.H. (2002)
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency
virus type 1 reverse transcriptase involves ATP-mediated excision. J. Virol.
76: 9143-9151. Julias,
J.G., McWilliams, M.J., Sarafianos, S.G., Arnold, E., and Hughes, S.H.
(2002) Mutations in the RNase H domain of HIV-1 reverse transcriptase affect
the initiation of DNA synthesis and the specificity of RNase H cleavage in
vivo. Proc. Natl. Acad. Sci. USA 99: 9515-9520. [Abstract] [Full-text
PDF
article] Rinke,
C.S., Boyer, P.L., Sullivan, M.D., Hughes, S.H., and Linial, M.L.
(2002) Mutation of the catalytic domain of the foamy virus reverse transcriptase
leads to loss of processivity and infectivity. J. Virol. 76: 7560-7570. Golinelli,
M.-P., and Hughes, S.H. (2002) Nontemplated nucleotide
addition by HIV-1 reverse transcriptase. Biochemistry 41: 5894-5906. Rausch,
J.W., Lener, D., Miller J.T., Julias, J.G., Hughes, S.H., and Le Grice,
S.F. (2002) Altering the RNase H primer grip of human immunodeficiency
virus reverse transcriptase modifies cleavage specificity. Biochemistry
41: 4856-4865. Tam,
W., Hughes, S.H., Hayward, W.S., and Besmer, P. (2002) Avian
bic, a gene isolated from a common retroviral site in avian leukosis virus-induced
lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis
and erythroleukemogenesis. J. Virol. 76: 4275-4286. Golinelli,
M.-P., and Hughes, S.H. (2002) Nontemplated base addition by
HIV-1 RT can induce nonspecific strand transfer in vitro. Virology 294:122-134. Boyer,
P.L., Sarafianos, S.G., Arnold, E., and Hughes, S.H. (2002)
The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate
(AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1.
J. Virol. 76: 3248-3256. [Abstract] [Full-text
PDF
article] Oh,
J., Julias, J.G., Ferris, A.L., and Hughes, S.H. (2002) Construction
and characterization of a replication-competent retroviral shuttle vector plasmid.
J. Virol. 76: 1762-1768. Gao,
H.Q., Sarafianos, S.G., Arnold, E., and Hughes, S.H. (2001)
RNase H cleavage of the 5' end of the human immunodeficiency virus type 1 genome.
J. Virol. 75: 11874-11880. Peletskaya,
E.N., Boyer, P.L., Kogon, A.A., Clark, P., Kroth, H., Sayer, J.M., Jerina, D.M.,
and Hughes, S.H. (2001) Cross-linking of the fingers subdomain
of human immunodeficiency virus type 1 reverse transcriptase to template-primer.
J. Virol. 75: 9435-9445. [Abstract] [Full-text
PDF
article] Golinelli,
M.-P., and Hughes, S.H. (2001) Self-priming of retroviral minus-strand
strong-stop DNAs. Virology 285: 278-290. [Abstract] [Full-text
PDF
article] Julias,
J.G., Ferris, A.L., Boyer, P.L., and Hughes, S.H. (2001) Replication
of phenotypically mixed human immunodeficiency virus type 1 virions containing
catalytically active and catalytically inactive reverse transcriptase. J.
Virol. 75: 6537-6546. Barsov,
E.V., Payne, W.S., and Hughes, S.H. (2001) Adaptation of chimeric
retroviruses in vitro and in vivo: Isolation of avian retroviral
vectors with extended host range. J. Virol. 75: 4973-4983. [Abstract] [Full-text
PDF
article] Boyer,
P.L., Sarafianos, S.G., Arnold, E., and Hughes, S.H. (2001)
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse
transcriptase. J. Virol. 75: 4832-4842. [Abstract] [Full-text
PDF
article] Sarafianos,
S.G., Das, K., Tantillo, C., Clark, A.D., Jr., Ding, J., Whitcomb, J.M., Boyer,
P.L., Hughes, S.H., and Arnold, E. (2001) Crystal structure
of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
EMBO J. 20: 1449-1461. Gao,
H.Q., Boyer, P.L., Sarafianos, S.G., Arnold, E., and Hughes, S.H. (2000)
The role of steric hindrance in 3TC resistance of human immunodeficiency virus
type-1 reverse transcriptase. J. Mol. Biol. 300: 403-418. [Abstract] [Full-text
PDF
article] Pinto,
V.B., Prasad, S., Yewdell, J., Bennink, J., and Hughes, S.H. (2000)
Restricting expression prolongs expression of foreign genes introduced into animals
by retroviruses. J. Virol. 74: 10202-10206. [Abstract] [Full-text
PDF
article] Sarafianos,
S.G., Das, K., Clark, A.D., Jr., Ding, J., Boyer, P.L., Hughes, S.H., and
Arnold, E. (1999) Lamivudine (3TC) resistance in HIV-1 reverse transcriptase
involves steric hindrance with b-branched
amino acids. Proc. Natl. Acad. Sci. USA 96: 10027-10032.
[Abstract] [Full-text
PDF
article] Zheng,
X.H., and Hughes, S.H. (1999) An avian sarcoma/leukosis virus-based
gene trap vector for mammalian cells. J. Virol. 73: 6946-6942. [Abstract] [Full-text
PDF
article] Coffin,
J.M., Hughes, S.H., and Varmus, H.E. (eds.). (1997) Retroviruses.
Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
[Link to Retroviruses
at the National Center for Biotechnology Information website] [For
more information, go to the Cold
Spring Harbor Laboratory Press website.] | ... |
