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Director, HIV Drug Resistance Program; Chief, Retroviral Replication Laboratory; and Head, Vector Design and Replication Section

HIV Drug Resistance Program
National Cancer Institute
NCI-Frederick, P.O. Box B, Building 539
Frederick, MD 21702-1201
Phone: 301-846-1619
Fax: 301-846-6966
E-mail: hughes@ncifcrf.gov


Dr. Stephen H. Hughes received his Ph.D. from Harvard University under the direction of Dr. Mario Capecchi and did postdoctoral research under the direction of Drs. J. Michael Bishop and Harold Varmus at the University of California, San Francisco.  From 1979 until 1984, Dr. Hughes was a Senior Staff Investigator at Cold Spring Harbor Laboratory.  In 1984, he established the Gene Expression in Eukaryotes Section in the ABL-Basic Research Program at NCI-Frederick.  Dr. Hughes became Deputy Director of the ABL-Basic Research Program in 1988 and Director of the Molecular Basis of Carcinogenesis Laboratory in 1995.  In 1999, he joined the HIV Drug Resistance Program in the National Cancer Institute as Chief of the Retroviral Replication Laboratory.  Dr. Hughes was appointed Director of the HIV Drug Resistance Program in 2006.  He is an Organizer of the Annual Symposium on Antiviral Drug Resistance and has served as an Organizer of the Retroviruses and Viral Vectors Meetings at Cold Spring Harbor Laboratory and the Annual Meeting on Oncogenes.  Dr. Hughes was named one of the most frequently cited AIDS researchers by Science Watch in 1996. 

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